The Botanic Garden usually puts on an exhibition relating to current or particularly relevant botanical themes every other year. Past exhibitions include:

2009 Darwin's Garden - Discover Evolution

2007 Gather, Explore, Preserve - 60 years of the Botanic Garden in Mainz

2005 The evolution of land vegetation

2003 Tropical crop plants

2002 The search for the dove tree

2001 Plants of the Bible

2000 Crop plants through the ages

1999 Scented plants

1998 Endangered plants in Rhineland-Palatinate

1996 The poppy

Guided tours of all the above exhibitions are still being offered.